看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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$ t2 F2 b+ ^9 H) hCurrently available feasibility data for possible combination strategies.
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0 [' B6 P7 l' i9 `Combination Feasibility according to preliminary data
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Bevacizumab + sorafenib Yes, reduced dose ! R3 A, j( a4 d7 g7 t. A+ s/ G
Bevacizumab + sunitinib† No
; M0 i/ G9 C' d; O1 N% i( V JBevacizumab + temsirolimus Yes
+ Z) E: M1 R6 K6 r- g5 Q F; M5 GBevacizumab + everolimus Yes
, _/ s( }6 Z& ]1 g/ PSorafenib + sunitinib ?
/ \5 s Q" h c7 y1 Z6 o8 c A& NSorafenib + temsirolimus Yes, reduced dose
% G( S9 t( H3 X- ]* tSorafenib + everolimus Yes, reduced dose ! |7 I3 v; w; g I; }0 J
Sunitinib + temsirolimus† No
) J8 l2 M+ Q1 ^, U' vSunitinib + everolimus ?
' `) z* }, ^7 {2 T( o, mTemsirolimus + everolimus ?
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†Led to US FDA warning.
. S, p( [; g' R N7 r6 p?: As yet unattempted combination., p p( N: F$ w! t) j& j X: t
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